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Top Harvard Cancer Researchers Accused of Scientific Fraud, 37 Studies Affected

Boston: Several top researchers from the Harvard-affiliated teaching hospital, the Dana-Farber Cancer Institute, were accused of manipulating image data (pictures of Western blots) with simple copy-and-past techniques. It is unknown how these manipulations change the outcome of the studies. The Dana-Farber Cancer Institute in Boston has already initiated six retractions to papers and 31 others are in the process of being corrected.

Sholto David, the man who discovered the manipulations, said, “”[W]e only see the tiny tip of the fraud iceberg – image data duplications, the last resort of a failed scientist after every other trick failed to provide the desired result, Billions of dollars were burned for this cancerous trash science, but it made many academic careers, some got very rich, and entire dynasties established themselves at Dana Farber.”

David said on his website that such fraud explains “why the progress in cancer research is so slow despite billions being invested into basic research.”

.Top Harvard cancer researchers, including Dana-Farber Cancer Institute President and CEO Laurie Glimcher, are being accused of faking data and committing scientific fraud.

From Ars Technica, “Top Harvard cancer researchers accused of scientific fraud; 37 studies affected”:

The Dana-Farber Cancer Institute, an affiliate of Harvard Medical School, is seeking to retract six scientific studies and correct 31 others that were published by the institute’s top researchers, including its CEO. The researchers are accused of manipulating data images with simple methods, primarily with copy-and-paste in image editing software, such as Adobe Photoshop.

The accusations come from [British molecular biologist] data sleuth Sholto David and colleagues on PubPeer, an online forum for researchers to discuss publications that has frequently served to spot dubious research and potential fraud. On January 2, David posted on his research integrity blog, For Better Science, a long list of potential data manipulation from DFCI researchers. The post highlighted many data figures that appear to contain pixel-for-pixel duplications. The allegedly manipulated images are of data such as Western blots, which are used to detect and visualize the presence of proteins in a complex mixture. DFCI Research Integrity Officer Barrett Rollins told The Harvard Crimson that David had contacted DFCI with allegations of data manipulation in 57 DFCI-led studies. Rollins said that the institute is “committed to a culture of accountability and integrity,” and that “every inquiry about research integrity is examined fully.”

The allegations are against: DFCI President and CEO Laurie Glimcher, Executive Vice President and COO William Hahn, Senior Vice President for Experimental Medicine Irene Ghobrial, and Harvard Medical School professor Kenneth Anderson.

David said on his website that such fraud explains “why the progress in cancer research is so slow despite billions being invested into basic research.”

David shared dozens of pictures like the one above showing dozens of researchers allegedly copy/pasting and faking their data.

“[W]e only see the tiny tip of the fraud iceberg – image data duplications, the last resort of a failed scientist after every other trick failed to provide the desired result,” David said. “Billions of dollars were burned for this cancerous trash science, but it made many academic careers, some got very rich, and entire dynasties established themselves at Dana Farber.”

Read full article here…

ARS Technica:        https://arstechnica.com/science/2024/01/top-harvard-cancer-researchers-accused-of-scientific-fraud-37-studies-affected/

NY Post:        https://nypost.com/2024/01/22/news/harvard-teaching-hospital-to-retract-papers-by-top-researchers/

from:    https://needtoknow.news/2024/01/top-harvard-cancer-researchers-accused-of-scientific-fraud-37-studies-affected/